State Route 43, a designated Virginia Scenic Byway, runs from Bedford through Buchanan and into Eagle Rock. Rolling countryside, mountain vistas, pastoral scenery, wildlife, native wildflowers, and picnic areas are abundant. The road condition is good, with the drive being it's most glorious from spring through fall.
In Bedford, visit the National D-Day Memorial. As you come across the Blue Ridge Parkway, take advantage of a stop at Peaks of Otter Lodge or hike the peaks themselves. Peaks of Otter Winery is nearby, too.
From the Parkway, head into Buchanan, a sweet small town with a main street of store fronts and the mighty James River coursing through it. If you're into kayaking, tubing or canoeing, this is a fantastic place to stop and enjoy the fresh air and beauty.
Continue on to Eagle Rock, where you'll definitely want to check out Roaring Run Furnace, a National Register site within Jefferson National Forest.